lsof meaning "list open files", which is used in many Unix-like systems to report a list of all open files and the processes that opened them.
Following can be used to show the largest 10 currently open files, the size of those files in Megabytes, and the name of the process holding the file open.
# lsof / | awk '{ if($7 > 1048576) print $7/1048576 "MB" " " $9 " " $1 }' | sort -n -u | tail